Poulos Constantine X., Le A.D., Parker J.L.
Biobehavioral Research Department, Addiction Research Foundation, 33 Russell St, Toronto, Ontario, Canada, M5S 2S1 and Psychology Department, University of Toronto, Toronto, Canada.
Behav Pharmacol. 1995 Dec;6(8):810-814.
Clinical studies indicate large individual differences in susceptibility to alcohol abuse. Poor behavioral self -regulation has been proposed to reflect a predisposing factor. Like humans, only some rats regularly consume large and intoxicating amounts of alcohol. We hypothesized that clinical indications of impaired behavioral self-regulation should be reflected in an animal model of impulse control, and in this study we assessed impulsivity with a delay-of-reward paradigm. We found that three groups representing three levels of impulsivity predicted augmenting levels of alcohol self-administration. Also, overall impulsivity scores were found to be significantly correlated with magnitude of alcohol self-administration. The finding that high impulsivity is linked to elevated consumption represents an animal model that may mirror clinical depictions of an alcohol abuse syndrome. This animal model may help elucidate the neurobiological basis of individual susceptibility to alcohol addiction.
临床研究表明，在酒精滥用易感性方面存在很大的个体差异。行为自我调节能力差被认为是一个诱发因素。和人类一样，只有一些大鼠会经常大量饮用致醉酒精。我们假设，行为自我调节受损的临床指征应在冲动控制的动物模型中得到体现，在本研究中，我们用奖励延迟范式评估冲动性。我们发现，代表三种冲动水平的三组大鼠预测了酒精自我给药水平的增加。此外，总体冲动性得分与酒精自我给药量显著相关。高冲动性与饮酒量增加有关这一发现代表了一种动物模型，它可能反映酒精滥用综合征的临床描述。这种动物模型可能有助于阐明个体对酒精成瘾易感性的神经生物学基础。
