Ali M A
Can Med Assoc J. 1975 Mar 22;112(6):701-2.
Between July 1973 and July 1974 all adult patients with hypochromic anemia and a mean corpuscular volume of 75 mum3 or less were screened for hemoglobinopathies. Of the 490 patients 105 had beta-thalassemia trait, 11 had alpha1-thalassemia trait, 4 had hemoglobin Lepore trait and 1 had hemoglobin H disease. Of 48 inpatients whose charts were reviewed 19 had been on oral iron therapy and 7 of them had been given iron intramuscularly. Of 27 outpatients interviewed 10 had been on intermittent iron therapy for 18 months or more; 4 had been given at least 1 g of intramuscular iron. Iron deficiency was not documented in any of these patients. Iron deficiency should be diagnosed by means other than the presence of a hypochromic picture in the peripheral blood before iron therapy is instituted, particularly in communities with a large population of Mediterranean or South-East Asian origin.
1973年7月至1974年7月期间，对所有成年低色素性贫血且平均红细胞体积为75立方微米或更小的患者进行血红蛋白病筛查。在490名患者中，105人有β地中海贫血特征，11人有α1地中海贫血特征，4人有血红蛋白Lepore特征，1人有血红蛋白H病。在审查病历的48名住院患者中，19人曾接受口服铁剂治疗，其中7人曾接受肌肉注射铁剂。在接受访谈的27名门诊患者中，10人曾接受间歇性铁剂治疗18个月或更长时间；4人曾接受至少1克肌肉注射铁剂。这些患者中均未记录有缺铁情况。在开始铁剂治疗之前，尤其是在地中海或东南亚裔人口众多的社区，缺铁应通过外周血低色素表现以外的其他方法来诊断。
