Seliger S L, Davis C, Stehman-Breen C
Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA.
Curr Opin Nephrol Hypertens. 2001 Mar;10(2):219-25. doi: 10.1097/00041552-200103000-00010.
Many studies of chronic renal disease have reported that men have a more rapid progression of renal insufficiency. However, other studies have found no differences between the sexes, and the true effect of sex on chronic renal disease remains a topic of controversy. There is evidence that women with non-diabetic renal diseases experience a slower progression, but in diabetic renal disease, the effect of gender is not yet established. Sex hormones may mediate the effects of gender on chronic renal disease, through alterations in the renin--angiotensin system, reduction in mesangial collagen synthesis, the modification of collagen degradation, and upregulation of nitric oxide synthesis.
许多关于慢性肾病的研究报告称，男性肾功能不全的进展更快。然而，其他研究并未发现两性之间存在差异，性别对慢性肾病的真正影响仍是一个有争议的话题。有证据表明，患有非糖尿病肾病的女性病情进展较慢，但在糖尿病肾病中，性别影响尚未明确。性激素可能通过肾素 - 血管紧张素系统的改变、系膜胶原合成的减少、胶原降解的改变以及一氧化氮合成的上调来介导性别对慢性肾病的影响。
