Micheau C, Guerinot F, Bohuon C, Brugere J
Cancer. 1975 May;35(5):1309-12. doi: 10.1002/1097-0142(197505)35:5<1309::aid-cncr2820350509>3.0.co;2-5.
In a case of olfactory esthesioneuroma, of which an unfixed specimen and blood sample were available, we demonstrated immunohistochemically and biochemically the presence of dopamine-B-hydroxylase and catecholamines in low concentration. This result indicates that this nasal tumor is probably of sympathetic origin, in whole or in part, and provides a new aid in diagnosis. Furthermore, biochemical assay of dopamine, V.M.A., and H.V.A. excretion in urine could perhaps bring information of diagnostic and prognostic value before and after treatment.
在一例可获取未固定标本和血液样本的嗅神经母细胞瘤病例中，我们通过免疫组织化学和生物化学方法证实了低浓度多巴胺-β-羟化酶和儿茶酚胺的存在。这一结果表明，这种鼻腔肿瘤可能全部或部分起源于交感神经，为诊断提供了新的辅助手段。此外，对尿液中多巴胺、香草扁桃酸和高香草酸排泄量的生化检测或许能在治疗前后提供具有诊断和预后价值的信息。
