Srigley J R, Dayal V S, Gregor R T, Love R, van Nostrand A W
Arch Otolaryngol. 1983 Aug;109(8):559-62. doi: 10.1001/archotol.1983.00800220065016.
A patient with a four-year history of unexplained hyponatremia was seen with recurrent nasal discharge and was found to have a typical olfactory neuroblastoma. The clinical laboratory diagnostic studies suggested that the patient's sodium deficiency was secondary to the syndrome of inappropriate antidiuretic hormone. Subsequent resection of the neoplasm led to resolution of the hyponatremia, suggesting that a (tumor-associated) humoral factor, such as vasopressin or a vasopressinlike substance, was responsible for the electrolyte disturbance. A search of the literature disclosed one previous case of vasopressin-secreting nasal neuroblastoma.
一名有四年不明原因低钠血症病史的患者因反复流鼻涕就诊，被发现患有典型的嗅神经母细胞瘤。临床实验室诊断研究表明，患者的钠缺乏继发于抗利尿激素分泌异常综合征。随后肿瘤切除后低钠血症得到缓解，提示一种（与肿瘤相关的）体液因子，如血管加压素或血管加压素样物质，是电解质紊乱的原因。文献检索发现此前有一例分泌血管加压素的鼻腔神经母细胞瘤病例。
