Matsumoto K
Ainomemorial Hospital.
Nihon Rinsho. 2000 Nov;58(11):2283-7.
Amantadine is only effective for influenza A, but zanamivir and oseltamivir, neuramidase inhibitors are strongly effective for influenza A and B. At this time we are available for amantadine and zanamivir for influenza in Japan. Oseltamivir is now under investigation in Japan. In USA both new drugs have been approved by USA government. Influenza vaccine is the first line drug for prevention of influenza A and B. In cases influenza infection occurs, we should promptly select and give antiinfluenza drug for these patients during almost 5 days, considering renal condition. And we should keep in mind that these antiviral substances are not directly effective for inflammatory phenomenons which introduce the reduction of lung function. So we should use both therapies which include antiviral chemotherapy and serious rescue treatment for respiratory failure.
金刚烷胺仅对甲型流感有效，但扎那米韦和奥司他韦这两种神经氨酸酶抑制剂对甲型和乙型流感都有强效。目前在日本有金刚烷胺和扎那米韦可用于治疗流感。奥司他韦目前正在日本进行研究。在美国，这两种新药均已获得美国政府批准。流感疫苗是预防甲型和乙型流感的一线药物。在发生流感感染的情况下，我们应根据肾脏状况，在近5天内迅速为这些患者选择并给予抗流感药物。并且我们应该记住，这些抗病毒物质对导致肺功能下降的炎症现象没有直接疗效。因此，我们应同时采用抗病毒化疗和针对呼吸衰竭的重症抢救治疗这两种疗法。
