Kaji Masahide
Department of Internal Medicine, Kurume University Medical Center.
Nihon Rinsho. 2003 Nov;61(11):1975-9.
Neuraminidase inhibitor has changed the treatment of influenza dramatically. The drug is effective for both influenza A and B whereas amantadine, another anti-influenzal agent, inhibits influenza A virus infection but not B. Neuraminidase inhibitor blocks the process of release of influenza virus from infected cells and inhibit the virus transmission to the neighboring cells. Neuraminidase inhibitor improves the symptoms of influenza and shortens the duration of illness. It is emphasized that this drug should be given within forty-eight hours after the onset, and it must be not noted that the possibility of the drug resistant virus although it is observed infrequently. Prophylactic use of the drug is also discussed.
神经氨酸酶抑制剂极大地改变了流感的治疗方法。这种药物对甲型和乙型流感均有效，而另一种抗流感药物金刚烷胺仅抑制甲型流感病毒感染，对乙型无效。神经氨酸酶抑制剂可阻断流感病毒从受感染细胞中释放的过程，并抑制病毒向邻近细胞的传播。神经氨酸酶抑制剂可改善流感症状并缩短病程。需要强调的是，该药物应在发病后48小时内使用，尽管耐药病毒的出现很少见，但也必须注意到这种可能性。文中还讨论了该药物的预防性使用。
