Kim S C
Department of Urology, College of Medicine, Chung-Ang University, Seoul, Korea.
Asian J Androl. 2000 Sep;2(3):161-6.
We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and relaxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyperlipidemia in impotent patients; 2) erection response to intracavernous injection of papaverine in impotent patients with hyperlipidemia; 3) relaxation responses of isolated cavernosal smooth muscles to endothelium-independent and endothelium-dependent vasodilators in impotent patients with hypercholesterolemia or hypertriglyceridemia; 4) involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits; 5) effects of isolated lipoproteins and triglyceride, combined oxidized LDL plus triglyceride, and combined oxidized LDL plus HDL on contractile and relaxation response of rabbit cavernous smooth muscles; 6) involvement of e-NOS in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit. Hypercholesterolemia may cause impairment of endothelium-dependent relaxation. Oxidized LDL is the major causative cholesterol of the impaired relaxation response. A chain reaction, the production of superoxide radicals and functional impairment of eNOS may be a major cause of the functional impairment in the early stages of hypercholesterolemia.
我们进行了一系列研究，以探讨脂质代谢受损对海绵体平滑肌收缩和舒张反应的影响，并阐明其发病机制：1）阳痿患者中高脂血症的发生率；2）高脂血症阳痿患者海绵体内注射罂粟碱后的勃起反应；3）高胆固醇血症或高甘油三酯血症阳痿患者分离的海绵体平滑肌对非内皮依赖性和内皮依赖性血管扩张剂的舒张反应；4）超氧自由基在高胆固醇血症兔海绵体平滑肌内皮依赖性舒张受损中的作用；5）分离的脂蛋白和甘油三酯、氧化型低密度脂蛋白与甘油三酯联合、氧化型低密度脂蛋白与高密度脂蛋白联合对兔海绵体平滑肌收缩和舒张反应的影响；6）内皮型一氧化氮合酶在高胆固醇血症兔海绵体平滑肌内皮依赖性舒张受损中的作用。高胆固醇血症可能导致内皮依赖性舒张功能受损。氧化型低密度脂蛋白是舒张反应受损的主要致病性胆固醇。超氧自由基的产生和内皮型一氧化氮合酶的功能障碍的连锁反应可能是高胆固醇血症早期功能障碍的主要原因。
