Liu Guodong, Zhang Yuyang, Wu Xu, Zhang Wei, Jiang Hui, Zhang Xiansheng
Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Institute of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Int J Impot Res. 2024 Aug 29. doi: 10.1038/s41443-024-00972-w.
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and involves risk factors such as atherosclerosis and endothelial dysfunction. Since the atherogenic index of plasma (AIP) may be potentially valuable in predicting cardiovascular risk, we conducted a comprehensive analysis of the relationship between AIP and ED using large-scale data, as well as exploring its potential implications for clinical and future research. We screened the National Health and Nutrition Examination Survey (NHANES) database using R software, selected datasets from two study cycles for cross-sectional analysis, enrolled covariates and performed statistical analyses using multivariate logistic regression. Furthermore, sensitivity analyses were performed and the relationship between the AIP index and ED was further assessed using generalized additive model regression and smoothed curve fitting. After an initial filter of 21,161 participants, 1503 participants were included, and the AIP level in the ED group was 0.21 ± 0.02 compared with 0.08 ± 0.01 in the group without ED, which was analyzed to show a statistically significant difference between them (P < 0.0001), and the difference was further confirmed in the sensitivity analyses. We suggest that early assessment, intervention, and individualized treatment of ED in people with high AIP levels is warranted, as it not only improves sexual function but also reduces the risk of CVD. However, it was a limitation of this study that the study population was all from the US, and more research is needed in the future to elucidate the causal relationship between AIP and ED and the association in a wider population.
勃起功能障碍（ED）与心血管疾病（CVD）相关，涉及动脉粥样硬化和内皮功能障碍等危险因素。由于血浆致动脉粥样硬化指数（AIP）在预测心血管风险方面可能具有潜在价值，我们使用大规模数据对AIP与ED之间的关系进行了全面分析，并探讨了其对临床和未来研究的潜在意义。我们使用R软件筛选了美国国家健康与营养检查调查（NHANES）数据库，从两个研究周期中选择数据集进行横断面分析，纳入协变量并使用多变量逻辑回归进行统计分析。此外，进行了敏感性分析，并使用广义相加模型回归和平滑曲线拟合进一步评估了AIP指数与ED之间的关系。在对21161名参与者进行初步筛选后，纳入了1503名参与者，ED组的AIP水平为0.21±0.02，而无ED组为0.08±0.01，经分析两者之间存在统计学显著差异（P<0.0001），且该差异在敏感性分析中得到进一步证实。我们建议，对AIP水平高的人群进行ED的早期评估、干预和个体化治疗是有必要的，因为这不仅可以改善性功能，还可以降低CVD风险。然而，本研究的一个局限性是研究人群均来自美国，未来需要更多研究来阐明AIP与ED之间的因果关系以及在更广泛人群中的关联。
