Mannan A, Noujaim A A, Wiebe L I, Secord D C, Sanders E J, Silverberg D S
Clin Biochem. 1975 Feb;8(1):44-51. doi: 10.1016/s0009-9120(75)90536-6.
Long term maintenance of male Wistar rats following sub-total nephrectomy has been shown to alter carbohydrate metabolism. These rats frequently became hypoglycemic and concurrently demonstrated increased hepatic glycogen stores. Chemical analysis of glycogen revealed a significant increase in branching, with a concomitant decrease in glucose residues per segment. The influence of food intake and glycosuria are discussed. Decreased glycogen autolysis is attributed to increased glycogen branching in the uremic liver.
已表明，雄性Wistar大鼠在接受次全肾切除术后的长期维持会改变碳水化合物代谢。这些大鼠经常出现低血糖，同时肝脏糖原储备增加。糖原的化学分析显示分支显著增加，每段葡萄糖残基随之减少。文中讨论了食物摄入量和糖尿的影响。糖原自溶减少归因于尿毒症肝脏中糖原分支增加。
