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PEDF: Raising both hopes and questions in controlling angiogenesis.

作者信息

Chader G J

出版信息

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2122-4. doi: 10.1073/pnas.061024098.

DOI:10.1073/pnas.061024098
PMID:11226201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC33385/
Abstract
摘要

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Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy.房水中天然眼部抗血管生成因子色素上皮衍生因子(PEDF)含量低预示着糖尿病视网膜病变的进展。
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Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor.人色素上皮衍生因子(PEDF)的晶体结构,一种强效抗血管生成和促进神经突生长的因子。
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11131-5. doi: 10.1073/pnas.211268598. Epub 2001 Sep 18.

本文引用的文献

1
Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor.天然眼部抗血管生成剂色素上皮衍生因子预防缺血性视网膜病变
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2593-7. doi: 10.1073/pnas.031252398. Epub 2001 Jan 23.
2
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin.丝氨酸蛋白酶抑制剂抗凝血酶裂解构象的抗血管生成活性
Science. 1999 Sep 17;285(5435):1926-8. doi: 10.1126/science.285.5435.1926.
3
Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons.色素上皮衍生因子促进发育中的脊髓运动神经元的存活和分化。
J Comp Neurol. 1999 Sep 27;412(3):506-14.
4
Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration.色素上皮衍生因子(PEDF)可保护运动神经元免受慢性谷氨酸介导的神经退行性变。
J Neuropathol Exp Neurol. 1999 Jul;58(7):719-28. doi: 10.1097/00005072-199907000-00006.
5
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.色素上皮衍生因子:一种有效的血管生成抑制剂。
Science. 1999 Jul 9;285(5425):245-8. doi: 10.1126/science.285.5425.245.
6
Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons.色素上皮衍生因子对发育中的原代海马神经元谷氨酸毒性的神经保护作用。
J Neurosci Res. 1999 Jun 15;56(6):604-10. doi: 10.1002/(SICI)1097-4547(19990615)56:6<604::AID-JNR6>3.0.CO;2-B.
7
Effects of donor age on the expression of a marker of replicative senescence (EPC-1) in human dermal fibroblasts.供体年龄对人皮肤成纤维细胞中复制性衰老标志物(EPC-1)表达的影响。
J Cell Physiol. 1999 Apr;179(1):11-7. doi: 10.1002/(SICI)1097-4652(199904)179:1<11::AID-JCP2>3.0.CO;2-7.
8
Age-related expression of PEDF/EPC-1 in human endometrial stromal fibroblasts: implications for interactive senescence.人子宫内膜基质成纤维细胞中PEDF/EPC-1的年龄相关表达:对交互衰老的影响
Exp Cell Res. 1999 Feb 25;247(1):142-7. doi: 10.1006/excr.1998.4341.
9
Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site.色素上皮衍生因子(PEDF)与糖胺聚糖结合:结合位点分析
Biochemistry. 1998 Jul 28;37(30):10643-52. doi: 10.1021/bi9802317.
10
Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death.色素上皮衍生因子(PEDF)对未成熟而非成熟的小脑颗粒细胞具有不同的保护作用,可防止其发生凋亡性细胞死亡。
J Neurosci Res. 1998 Jul 1;53(1):7-15. doi: 10.1002/(SICI)1097-4547(19980701)53:1<7::AID-JNR2>3.0.CO;2-F.