Tombran-Tink J, Barnstable C J
Division of Pharmaceutical Sciences, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA.
Biochem Biophys Res Commun. 2004 Apr 2;316(2):573-9. doi: 10.1016/j.bbrc.2004.02.076.
Pigment epithelial derived factor (PEDF) is one of the most effective inhibitors of angiogenesis described so far, especially in controlling the growth of blood vessels in the eye. We now describe the localization of PEDF in regions of active bone formation in the mid-gestation mouse embryo and its specific and high levels of secretion by osteoblasts. PEDF is detected to a lesser extent in osteoclasts as well. The proangiogenic factors, VEGF and its receptors VEGF-R1 and VEGF-R2, are also expressed by both osteoblasts and osteoclasts. These findings suggest that bone angiogenesis and matrix remodeling may be mediated both by PEDF and by VEGF.
色素上皮衍生因子（PEDF）是迄今为止所描述的最有效的血管生成抑制剂之一，尤其在控制眼部血管生长方面。我们现在描述了PEDF在妊娠中期小鼠胚胎活跃骨形成区域的定位及其由成骨细胞特异性且高水平分泌的情况。在破骨细胞中也能检测到较少程度的PEDF。促血管生成因子血管内皮生长因子（VEGF）及其受体VEGF-R1和VEGF-R2，也由成骨细胞和破骨细胞表达。这些发现表明，骨血管生成和基质重塑可能由PEDF和VEGF共同介导。
