Watson J D, Dako D Y
Clin Chim Acta. 1975 Feb 22;59(1):55-61. doi: 10.1016/0009-8981(75)90218-1.
The erythrocyte transketolase activity, and the effect of thiamin pyrophosphate stimulation (TPP effect) on this enzyme, was determined in 263 adult Ghanaian subjects who included normal males and females, male labourers known to consume a diet high in carbohydrate, diabetics and pregnant women. Using the guideline that a TPP effect of greater than 25% indicates thiamin deficiency, it was found that a significant proportion of apparently healthy subjects (36%-47%) may be regarded as thiamin deficient. The results are discussed in the light of similar studies carried out by other workers.
在263名成年加纳受试者中测定了红细胞转酮醇酶活性以及硫胺素焦磷酸刺激（TPP效应）对该酶的影响，这些受试者包括正常男性和女性、已知食用高碳水化合物饮食的男性劳动者、糖尿病患者和孕妇。根据TPP效应大于25%表明硫胺素缺乏这一准则，发现相当一部分看似健康的受试者（36%-47%）可能被视为硫胺素缺乏。根据其他研究人员进行的类似研究对结果进行了讨论。
