Schredl M, Weber B, Leins M L, Heuser I
Sleep Laboratory, Central Institute of Mental Health, P.O. Box 122120, 68072, Mannheim, Germany.
Exp Gerontol. 2001 Feb;36(2):353-61. doi: 10.1016/s0531-5565(00)00206-0.
Previous research in younger individuals has shown that acetylcholinesterase inhibitors may enhance REM sleep. The present study indicates that in the elderly, donepezil, an acetylcholinesterase inhibitor, also exerts a marked effect on REM sleep parameters--percentage of REM sleep and REM density were increased whereas REM latency was reduced. In addition, we also found a correlation between memory performance and REM sleep. Based on these findings, we conclude that there is an interrelationship between cognitive performance and amount of REM sleep in elderly humans as has been previously shown in animals and young adults.
先前针对较年轻个体的研究表明，乙酰胆碱酯酶抑制剂可能会增强快速眼动睡眠。本研究表明，在老年人中，乙酰胆碱酯酶抑制剂多奈哌齐对快速眼动睡眠参数也有显著影响——快速眼动睡眠百分比和快速眼动密度增加，而快速眼动潜伏期缩短。此外，我们还发现记忆表现与快速眼动睡眠之间存在关联。基于这些发现，我们得出结论，正如先前在动物和年轻人中所显示的那样，老年人的认知表现与快速眼动睡眠量之间存在相互关系。
