Estines O, Grosieux-Dauger C, Derancourt C, Patey M, Durlach A, Bernard P
Service de Dermatologie, CHU Robert Debré, Reims.
Ann Dermatol Venereol. 2001 Jan;128(1):31-4.
Paraneoplastic ichthyosis is a rare affection generally associated with malignant hemopathy.
A 61 year-old man was seen with a generalized ichthyosis associated with a palmoplantar hyperkeratosis developed over the last 2 years, and an axillary lymph node. Histology of the lymph node revealed a large cell anaplastic lymphoma. Both ichthyosis and palmoplantar keratosis totally disappeared three weeks after adenectomy, without any other treatment.
This rapid and complete regression of ichthyosis, after the sole ablation of the involved lymph node confirmed the paraneoplastic nature of the disorders of the keratinization (ichtyosis, palmoplantar keratodermia). The review of the literature showed only one case characterized by a rapid disappearance of ichthyosis after surgical treatment of the malignant lymphoma.
副肿瘤性鱼鳞病是一种罕见的疾病,通常与恶性血液病相关。
一名61岁男性,在过去两年中出现了伴有掌跖角化过度的全身性鱼鳞病以及一个腋窝淋巴结。淋巴结组织学检查显示为大细胞间变性淋巴瘤。在未进行任何其他治疗的情况下,腺切除术后三周,鱼鳞病和掌跖角化症完全消失。
仅切除受累淋巴结后,鱼鳞病迅速且完全消退,这证实了角化异常疾病(鱼鳞病、掌跖角化病)的副肿瘤性质。文献回顾显示,仅有一例在恶性淋巴瘤手术治疗后鱼鳞病迅速消失。