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产前接触大麻的影响。

Effects of prenatal exposure to marijuana.

作者信息

Kozer E, Koren G

机构信息

Hospital for Sick Children, Toronto.

出版信息

Can Fam Physician. 2001 Feb;47:263-4.

PMID:11228023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2016243/
Abstract

QUESTION

I am treating a 27-year-old woman who is now in her 10th week of pregnancy. She smokes marijuana two to three times a week, but does not use other drugs. She also smokes 20 cigarettes a day. I am concerned about the effects of marijuana exposure on her baby.

ANSWER

It is not always possible to isolate the effect of marijuana exposure from other possible confounders on pregnancy outcome. Although marijuana is not an established human teratogen, recent well conducted studies suggest it might have subtle negative effects on neurobehavioural outcomes, including sleep disturbances, impaired visual problem solving, hyperactivity, impassivity, inattention, and increased delinquency.

摘要

问题

我正在治疗一名27岁的女性,她现在处于怀孕第10周。她每周吸食大麻两到三次,但不使用其他毒品。她每天还吸20支烟。我担心接触大麻会对她的宝宝产生影响。

答案

要将接触大麻的影响与其他可能的混杂因素对妊娠结局的影响区分开来并不总是可行的。虽然大麻并非公认的人类致畸物,但最近开展的一些良好研究表明,它可能对神经行为结局有微妙的负面影响,包括睡眠障碍、视觉问题解决能力受损、多动、冷漠、注意力不集中以及犯罪行为增加。

相似文献

1
Effects of prenatal exposure to marijuana.产前接触大麻的影响。
Can Fam Physician. 2001 Feb;47:263-4.
2
The effects of prenatal alcohol and marijuana exposure: disturbances in neonatal sleep cycling and arousal.产前酒精和大麻暴露的影响:新生儿睡眠周期和觉醒的紊乱。
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Smoking and marijuana use in pregnancy.孕期吸烟与使用大麻。
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Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics.产前酒精暴露:对婴儿生长和形态特征的影响。
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60- and 72-month follow-up of children prenatally exposed to marijuana, cigarettes, and alcohol: cognitive and language assessment.对产前暴露于大麻、香烟和酒精环境中的儿童进行60个月和72个月的随访:认知和语言评估
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Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood.孕期母亲吸烟与随访至成年期的后代精神病理学研究。
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Cigarettes and marijuana: are there measurable long-term neurobehavioral teratogenic effects?香烟与大麻:是否存在可测量的长期神经行为致畸效应?
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引用本文的文献

1
Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines.大麻二酚改变滋养层细胞系中 P-糖蛋白和 BCRP 的表达。
PeerJ. 2013 Sep 12;1:e153. doi: 10.7717/peerj.153. eCollection 2013.
2
Canada's youth up in smoke: The decriminalization of cannabis.加拿大青少年吸烟问题:大麻合法化。
Paediatr Child Health. 2003 Nov;8(9):553. doi: 10.1093/pch/8.9.553.

本文引用的文献

1
Drug therapy for breast-feeding women.哺乳期妇女的药物治疗。
N Engl J Med. 2000 Jul 13;343(2):118-26. doi: 10.1056/NEJM200007133430208.
2
Effects of prenatal marijuana exposure on child behavior problems at age 10.产前暴露于大麻对10岁儿童行为问题的影响。
Neurotoxicol Teratol. 2000 May-Jun;22(3):325-36. doi: 10.1016/s0892-0362(00)00066-0.
3
Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and marihuana.产前接触香烟和大麻的9至12岁儿童的视觉感知功能存在差异。
Neurotoxicol Teratol. 2000 Jan-Feb;22(1):11-20. doi: 10.1016/s0892-0362(99)00046-x.
4
Maternal cannabis use and birth weight: a meta-analysis.母亲使用大麻与出生体重:一项荟萃分析。
Addiction. 1997 Nov;92(11):1553-60.
5
Mortality within the first 2 years in infants exposed to cocaine, opiate, or cannabinoid during gestation.孕期接触可卡因、阿片类药物或大麻素的婴儿在出生后2年内的死亡率。
Pediatrics. 1997 Jul;100(1):79-83. doi: 10.1542/peds.100.1.79.
6
Substance abuse in pregnancy.
Curr Opin Obstet Gynecol. 1993 Feb;5(1):16-23.
7
Parents' use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children.父母使用可卡因和大麻与子女患横纹肌肉瘤的风险增加
Cancer Causes Control. 1993 May;4(3):217-24. doi: 10.1007/BF00051316.
8
Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study.牙买加的产前大麻暴露与新生儿结局:一项人种志研究。
Pediatrics. 1994 Feb;93(2):254-60.
9
Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy?儿童急性非淋巴细胞白血病的危险因素:与孕期母亲饮酒有关联吗?
Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):457-60.
10
A longitudinal study of prenatal marijuana use. Effects on sleep and arousal at age 3 years.一项关于产前使用大麻的纵向研究。对3岁儿童睡眠和觉醒的影响。
Arch Pediatr Adolesc Med. 1995 Feb;149(2):145-50. doi: 10.1001/archpedi.1995.02170140027004.