Merlo J, Ostergren P O, Månsson N O, Hanson B S, Ranstam J, Blennow G, Isacsson S O, Melander A
Department of Community Medicine, Malmö University Hospital, Lund University, Malmö, Sweden.
Scand J Public Health. 2000 Dec;28(4):294-7.
Insufficient coping with stress may lead to increased susceptibility for disease and death. Use of anxiolytic-hypnotic drugs has been suggested as a coping strategy, and some opinions have proposed their use as preventive medication. The aim of this study was to estimate if use of anxiolytic-hypnotic drugs counters the increased mortality observed in individuals lacking other coping strategies such as emotional support and social participation.
A population based cohort study with 10-year (1982/83-1993) survival analysis was performed in 491 men born in 1914, living in the Swedish city of Malmö.
Compared with men with a high level of psychosocial coping resources who did not use anxiolytic-hypnotic drugs, men with a low level of psychosocial coping resources had a higher risk of death irrespective whether they used anxiolytic-hypnotic drugs, RR = 1.7 (95% CI 1.1-2.6) or not RR = 1.8 (95%: 1.3-2.5).
Anxiolytic-hypnotic drugs do not seem to counter increased mortality in elderly men with low psychosocial coping resources.
应对压力不足可能会增加患病和死亡的易感性。有人建议使用抗焦虑催眠药物作为一种应对策略，并且一些观点提议将其用作预防性药物。本研究的目的是评估抗焦虑催眠药物的使用是否能抵消在缺乏诸如情感支持和社会参与等其他应对策略的个体中所观察到的死亡率增加的情况。
对491名1914年出生、居住在瑞典马尔默市的男性进行了一项基于人群的队列研究，并进行了为期10年（1982/83 - 1993年）的生存分析。
与心理社会应对资源水平高且未使用抗焦虑催眠药物的男性相比，心理社会应对资源水平低的男性无论是否使用抗焦虑催眠药物，死亡风险都更高，使用时相对危险度（RR）= 1.7（95%置信区间1.1 - 2.6），未使用时RR = 1.8（95%：1.3 - 2.5）。
抗焦虑催眠药物似乎无法抵消心理社会应对资源水平低的老年男性中增加的死亡率。
