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一项针对台湾社区居住的老年人群体的睡眠模式与死亡率的九年随访研究。

A nine-year follow-up study of sleep patterns and mortality in community-dwelling older adults in Taiwan.

机构信息

Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.

出版信息

Sleep. 2013 Aug 1;36(8):1187-98. doi: 10.5665/sleep.2884.

Abstract

STUDY OBJECTIVES

To simultaneously explore the associations between mortality and insomnia, sleep duration, and the use of hypnotics in older adults.

DESIGN

A fixed cohort study.

SETTING

A community in Shih-Pai area, Taipei, Taiwan.

PARTICIPANTS

A total of 4,064 participants over the age of 65 completed the study.

INTERVENTION

N/A.

MEASUREMENTS AND RESULTS

Insomnia was classified using an exclusionary hierarchical algorithm, which categorized insomnia as "no insomnia," "subjective poor sleep quality," "Pittsburgh Sleep Quality Index > 5 insomnia," "1-month insomnia disorder," and "6-month insomnia disorder." The main outcome variables were 9-year all-cause mortality rates. In the all-cause mortality analyses, when hypnotic use, depressive symptoms and total sleep time were excluded from a proportional hazards regression model, subjects with "Pittsburgh Sleep Quality Index > 5 insomnia" had a higher mortality risk (HR: 1.21, 95% CI: 1.01-1.45). In the full model, frequent hypnotic use and long sleep duration predicted higher mortality rates. However, the increased mortality risk for subjects with "Pittsburgh Sleep Quality Index > 5 insomnia" was not observed in the full model. On the contrary, individuals with a 6-month DSM-IV insomnia disorder had a lower risk for premature death (HR: 0.64, 95% CI: 0.43-0.96).

CONCLUSIONS

Long sleep duration and frequent hypnotics use predicted an increased mortality risk within a community-dwelling sample of older adults. The association between insomnia and mortality was affected by insomnia definition and other parameters related to sleep patterns.

摘要

研究目的

同时探讨老年人死亡率与失眠、睡眠时间和催眠药物使用之间的关系。

设计

固定队列研究。

地点

台湾台北市石牌地区的一个社区。

参与者

共有 4064 名 65 岁以上的参与者完成了研究。

干预措施

无。

测量和结果

使用排除性分层算法对失眠进行分类,将失眠分为“无失眠”、“主观睡眠质量差”、“匹兹堡睡眠质量指数>5 分的失眠”、“1 个月失眠障碍”和“6 个月失眠障碍”。主要观察结果是 9 年全因死亡率。在全因死亡率分析中,当催眠药物使用、抑郁症状和总睡眠时间被排除在比例风险回归模型之外时,匹兹堡睡眠质量指数>5 分的患者死亡率较高(HR:1.21,95%CI:1.01-1.45)。在全模型中,频繁使用催眠药物和长时间睡眠与更高的死亡率相关。然而,在全模型中,没有观察到匹兹堡睡眠质量指数>5 分的患者死亡率增加的风险。相反,患有 6 个月 DSM-IV 失眠障碍的个体过早死亡的风险较低(HR:0.64,95%CI:0.43-0.96)。

结论

在社区居住的老年人群体中,长时间睡眠和频繁使用催眠药物预示着更高的死亡率风险。失眠与死亡率之间的关系受失眠定义和其他与睡眠模式相关的参数的影响。

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