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[法国及全球抗焦虑和催眠药物的使用流行病学]

[Epidemiology of the use of anxiolytic and hypnotic drugs in France and in the world].

作者信息

Pélissolo A, Boyer P, Lépine J P, Bisserbe J C

机构信息

Service de Psychiatrie, Hôpital Fernand-Widal, Paris.

出版信息

Encephale. 1996 May-Jun;22(3):187-96.

PMID:8767047
Abstract

A higher anxiolytic and hypnotic consumption has been evidenced in France by recent international and national surveys. In an effort to counteract this pattern French Health authorities have enforced limitation to the prescription of these drugs. Understanding the causes of this overuse needs a careful analysis of the pattern of use of this medicine but also of the associated morbidity factors. In the last ten years several studies have attempted to address these issues. In the general population there were 25 to 30% of occasional or regular users with between 5 and 7% chronic users making french anxiolytic users two to three time superior to most industrialised countries. This high level of consumption is not the privilege of anxiolytic since the same pattern of use is observed for all medicine. Studies in primary care, in medical inpatients and psychiatric inpatients show as expected that anxiolytic use increase with the psychiatric morbidity and also with somatic disorder. The main risk factors for anxiolytic use are female sex, old age and psychic and somatic morbidity. Age seems to play a major role in subjects over 65: 17% are chronic users. Multiple factors might play a role in benzodiazepine use as medical care system, physician type of practice, cultural specific aspects but no proper simple explanation is available to explain the mechanism of the french high anxiolytic use. Given the poor global recognition of mental disorder observed in most countries it is suggested to privilege primary care physician training in psychiatry to optimize psychotropic drug use.

摘要

近期的国际和国内调查表明,法国的抗焦虑药和催眠药消费量较高。为了应对这种情况,法国卫生当局已对这些药物的处方实施了限制。要了解这种药物过度使用的原因,需要仔细分析这种药物的使用模式以及相关的发病因素。在过去十年中,有几项研究试图解决这些问题。在普通人群中,有25%至30%的偶尔或定期使用者,其中5%至7%为长期使用者,这使得法国抗焦虑药使用者的数量是大多数工业化国家的两到三倍。这种高消费量并非抗焦虑药所独有,所有药物的使用模式都是如此。在初级保健、内科住院患者和精神科住院患者中的研究表明,正如预期的那样,抗焦虑药的使用随着精神疾病发病率以及躯体疾病的增加而增加。使用抗焦虑药的主要风险因素是女性、老年以及精神和躯体疾病。年龄似乎在65岁以上的人群中起主要作用:17%为长期使用者。多种因素可能在苯二氮䓬类药物的使用中起作用,如医疗保健系统、医生的执业类型、文化特定方面,但目前尚无合适的简单解释来说明法国抗焦虑药高消费量的机制。鉴于大多数国家对精神障碍的整体认知不足,建议优先对初级保健医生进行精神病学培训,以优化精神药物的使用。

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