Houghton A N, Gold J S, Blachere N E
Memorial Sloan-Kettering Cancer Center and Weill Medical School of Cornell University, 1275 York Avenue, New York, NY 10021, USA.
Curr Opin Immunol. 2001 Apr;13(2):134-40. doi: 10.1016/s0952-7915(00)00195-3.
Most major advances in human cancer immunology and immunotherapy have come from studies in melanoma. We are beginning to understand the immune repertoire of T cells and antibodies that are active against melanoma, with recent glimpses of the CD4(+) T cell repertoire. The view of what the immune system can see is extending to mutations and parts of the genome that are normally invisible.
人类癌症免疫学和免疫疗法的大多数重大进展都来自黑色素瘤研究。我们开始了解对黑色素瘤有活性的T细胞和抗体的免疫库，最近对CD4(+) T细胞库也有所了解。免疫系统所能识别的范围正在扩展到通常不可见的突变和基因组部分。
