个体化治疗：转移性黑色素瘤的新型抗原疫苗。
Making It Personal: Neoantigen Vaccines in Metastatic Melanoma.
机构信息
Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10028, USA.
Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10028, USA; Adaptive Biotechnologies, 1551 Eastlake Ave. E, Ste 200, Seattle, WA 98102, USA.
出版信息
Immunity. 2017 Aug 15;47(2):221-223. doi: 10.1016/j.immuni.2017.08.001.
Somatic mutations in cancer can be translated into peptides, termed neoantigens, which can be recognized by the immune system as "foreign" epitopes. Two recent studies in Nature (Sahin et al., 2017; Ott et al., 2017) examine the effects of neoantigen vaccines on patients with stage III or IV melanoma and demonstrate immunogenicity and intriguing clinical safety and efficacy data in phase I studies.
癌症中的体细胞突变可以被翻译为肽，称为新抗原，这些新抗原可以被免疫系统识别为“外来”表位。最近 Nature 杂志上的两项研究（Sahin 等人，2017 年；Ott 等人，2017 年）探讨了新抗原疫苗对 III 期或 IV 期黑色素瘤患者的影响，并在 I 期研究中展示了免疫原性和有趣的临床安全性和疗效数据。
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