丹麦女性孕期B族链球菌定植与早产之间的关联。
Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women.
作者信息
Feikin D R, Thorsen P, Zywicki S, Arpi M, Westergaard J G, Schuchat A
机构信息
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA.
出版信息
Am J Obstet Gynecol. 2001 Feb;184(3):427-33. doi: 10.1067/mob.2001.109936.
OBJECTIVE
We studied the relationship between group B streptococcal colonization and preterm delivery.
STUDY DESIGN
In this prospective study at a single hospital in Odense, Denmark, cervicovaginal cultures were obtained at < or = 24 weeks' gestation from all the women, at delivery from women with preterm deliveries, and from a random sample of women delivering at term.
RESULTS
In 2846 singleton births, there was no significant association between group B streptococcal colonization at <or = 24 weeks' gestation and preterm birth. After adjustment for the risk factors for preterm delivery, more women with preterm delivery (12/84, 14%) were colonized at delivery with group B streptococci than women with term deliveries (22/300, 7%; adjusted odds ratio, 3.0; 95% confidence interval, 1.4-6.8). Group B streptococcal colonization at < or = 24 weeks' gestation and at delivery was significantly less likely to occur in the presence of normal vaginal flora.
CONCLUSION
Group B streptococcal colonization at delivery, but not at < or = 24 weeks' gestation, was associated with preterm delivery.
目的
我们研究了B族链球菌定植与早产之间的关系。
研究设计
在丹麦欧登塞市一家医院进行的这项前瞻性研究中，在妊娠≤24周时对所有女性进行宫颈阴道培养，对早产女性在分娩时进行培养，并从足月分娩的女性中随机抽取样本进行培养。
结果
在2846例单胎分娩中，妊娠≤24周时B族链球菌定植与早产之间无显著关联。在对早产风险因素进行调整后，早产女性中分娩时B族链球菌定植的比例（12/84，14%）高于足月分娩女性（22/300，7%；校正优势比为3.0；95%置信区间为1.4 - 6.8）。在存在正常阴道菌群的情况下，妊娠≤24周时和分娩时B族链球菌定植的可能性显著降低。
结论
分娩时而非妊娠≤24周时的B族链球菌定植与早产有关。
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