Dubus J C
Service de Médecine Infantile, CHU Timone-Enfants, F13385 Marseille.
Presse Med. 2001 Feb 3;30(4):182-6.
IMPROVED DRUG DELIVERY: Spacer devices improve the pulmonary deposition of drugs delivered from pressurized metered-dose inhalers because they decrease the diameter of the aerosol particles. Spacer devices are the best delivery system of inhaled drugs in children younger than 8 years.
Small volume spacer devices, with inspiratory and expiratory valves, are particularly interesting to use. The use of a facemask is only recommended in the youngest and the oldest have to breathe through the mouth piece. Electrostatism is generated from the plastic walls of the spacer devices and decreases the drug delivery. Using a metallic spacer device or washing a plastic spacer device with a domestic detergent, without rinsing with water nor rubbing the walls, avoids this problem. OPTIMAL USE: Spacer devices are not generics. Each drug has a specific behaviour in a spacer device. Correct inhalatory technique has to be checked at each visit for an optimal efficacy of the treatment.
改善药物递送:储雾罐装置可改善从压力定量吸入器递送的药物在肺部的沉积,因为它们减小了气溶胶颗粒的直径。储雾罐装置是8岁以下儿童吸入药物的最佳递送系统。
带有吸气和呼气阀的小容量储雾罐装置尤其值得使用。仅建议最年幼的儿童使用面罩,年龄较大的儿童必须通过吸嘴呼吸。储雾罐装置的塑料壁会产生静电,从而降低药物递送效果。使用金属储雾罐装置或用家用洗涤剂清洗塑料储雾罐装置,无需用水冲洗也无需擦拭壁面,可避免此问题。最佳使用方法:储雾罐装置并非通用。每种药物在储雾罐装置中的行为都有其特殊性。每次就诊时都必须检查正确的吸入技术,以实现最佳治疗效果。