Holroyde M C, Eyre P
Eur J Pharmacol. 1975 Jan;30(1):43-8. doi: 10.1016/0014-2999(75)90200-9.
This study was designed to investigate the splanchnic congestion and gastrointestinal lesions frequently found in calves during anaphylaxis. Calves were sensitised to horse serum and the following cardiovascular parameters monitored; carotid arterial pressure, mesenteric arterial pressure, mesenteric venous pressure, mesenteric arterial flow, and abdominal venous pressure. Responses to histamine, 5-hydroxytryptamine (5HT), bradykinin, dopamine, noradrenaline and horse serum were recorded. Anaphylaxis was characterised by a diphasic arterial hypotension, a parallel rise in mesenteric venous pressure, a fall in mesenteric arterial flow and a threefold rise in mesenteric vascular resistance. It is suggested that during anaphylaxis a rise in hepatic vascular resistance occurs, resulting in pooling of blood in the venous side of the mesenteric vasculature and possibly in the liver itself. This increase in hepatic resistance may be caused by circulating vasoactive agents released by the anaphylactic process, a local Schultz-Dale type reaction, or a reflex triggered by systemic baroreceptors.
本研究旨在调查犊牛过敏反应期间常见的内脏充血和胃肠道病变。使犊牛对马血清致敏，并监测以下心血管参数：颈动脉压、肠系膜动脉压、肠系膜静脉压、肠系膜动脉血流量和腹静脉压。记录对组胺、5-羟色胺（5HT）、缓激肽、多巴胺、去甲肾上腺素和马血清的反应。过敏反应的特征为双相性动脉低血压、肠系膜静脉压平行升高、肠系膜动脉血流量下降以及肠系膜血管阻力增加三倍。有人提出，在过敏反应期间，肝血管阻力升高，导致血液在肠系膜血管系统的静脉侧以及可能在肝脏本身中淤积。肝阻力的这种增加可能是由过敏反应过程中释放的循环血管活性物质、局部舒尔茨 - 戴尔型反应或全身压力感受器触发的反射引起的。
