5-羟色胺对牛粒细胞过敏性组胺释放的抑制作用。
Inhibition by 5-hydroxytryptamine of anaphylactic histamine release from bovine granulocytes.
作者信息
Holroyde M C, Eyre P
出版信息
Eur J Pharmacol. 1976 Jun;37(2):397-9. doi: 10.1016/0014-2999(76)90050-9.
PMID:60245
Abstract
A suspension of granulocytes from calves sensitised to horse plasma released histamine when exposed to the antigen. Histamine release was strongly inhibited by 5-hydroxytryptamine in a dose-related fashion. 5-HT is known to be released from bovine lungs in vitro, and may regulate the release of histamine in vivo during anaphylaxis.
摘要
来自对马血浆致敏的小牛的粒细胞悬液在接触抗原时会释放组胺。5-羟色胺以剂量相关的方式强烈抑制组胺释放。已知5-羟色胺在体外可从牛肺中释放，并且在过敏反应期间可能在体内调节组胺的释放。
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