Holroyde M C, Eyre P
Eur J Pharmacol. 1975 Jan;30(1):36-42. doi: 10.1016/0014-2999(75)90199-5.
In an attempt to investigate the possible contribution of the mesenteric and hepatic vasculature to the haemodynamic changes occurring during bovine systemic anaphylaxis, the pharmacological reactivity of isolated bovine mesenteric and hepatic veins was studied. Both mesenteric and hepatic veins contracted in the presence of histamine, 5-hydroxytryptamine (5HT), acetylcholine, dopamine and noradrenaline, and relaxed in the presence of isoprenaline. The mesenteric veins contracted in the presence of concentrations of isoprenaline greater than 1 mug/ml. By the use of antagonists, the receptor populations of bovine mesenteric and hepatic veins were shown to be similar to those of many other vascular preparations. Hepatic veins isolated from calves previously sensitised to horse serum contracted forcefully in the presence of horse plasma (the Schultz-Dale phenomenon), whereas mesenteric veins isolated from the same animals did not. Hepatic veins may be implicated in the haemodynamics of bovine systemic anaphylaxis.
为了研究肠系膜和肝血管系统对牛全身性过敏反应期间发生的血流动力学变化可能产生的影响，对离体牛肠系膜静脉和肝静脉的药理反应性进行了研究。肠系膜静脉和肝静脉在组胺、5-羟色胺（5HT）、乙酰胆碱、多巴胺和去甲肾上腺素存在时收缩，在异丙肾上腺素存在时舒张。当异丙肾上腺素浓度大于1微克/毫升时，肠系膜静脉收缩。通过使用拮抗剂，发现牛肠系膜静脉和肝静脉的受体类型与许多其他血管制剂的受体类型相似。从先前对马血清致敏的小牛分离出的肝静脉在马血浆存在时强烈收缩（舒尔茨-戴尔现象），而从同一动物分离出的肠系膜静脉则没有。肝静脉可能与牛全身性过敏反应的血流动力学有关。
