Zimmerman H J
Armed Forces Institute of Pathology, Washington, DC, USA.
Clin Liver Dis. 2000 Feb;4(1):73-96, vi. doi: 10.1016/s1089-3261(05)70097-0.
Drug-induced liver disease may account for between 10% and 50% of adult patients with elevated enzymes, especially in patients over age 50 years. It accounts for nearly 25% of patients with fulminant hepatic failure. Liver injury can be cytotoxic, cholestatic, or mixed. A variety of systemic manifestations can accompany drug-induced hepatotoxicity. Drug-induced liver disease can mimic autoimmune hepatitis or it can evolve to cirrhosis. It can also mimic veno-occulusive disorders. The plethora of herbal and traditional agents currently ingested by many people should always be considered in any patient with abnormal hepatic biochemistry.
药物性肝病可能占成人酶升高患者的10%至50%，尤其是50岁以上的患者。它占暴发性肝衰竭患者的近25%。肝损伤可以是细胞毒性、胆汁淤积性或混合性的。药物性肝毒性可伴有多种全身表现。药物性肝病可模仿自身免疫性肝炎，也可发展为肝硬化。它还可模仿静脉闭塞性疾病。对于任何肝生化异常的患者，都应始终考虑到目前许多人大量摄入的草药和传统药物。
