Kotake Y
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Antioxid Redox Signal. 1999 Winter;1(4):481-99. doi: 10.1089/ars.1999.1.4-481.
Phenyl N-tert-butylnitrone (PBN) is the parent of a family of nitrones used as spin-trapping agents to trap free radicals. PBN's pharmacological effects in animal models are extensive, ranging from protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to increasing the life span of mice. Recent additions to the list include protection from bacterial meningitis, thalidomide-induced teratogenicity, drug-induced diabetogenesis, and choline-deficient hepatocarcinogenesis. Because PBN reacts with oxygen radicals to produce less reactive species, it has been suggested that this is the basis of its pharmacological effects. However, there has been no hard evidence for this notation. Nevertheless, many investigators have used the presence of PBN's pharmacologic effect as evidence for free radical involvement in their models. Mechanistic studies on the PBN's antisepsis action revealed that PBN inhibits expression of various pro-inflammatory genes, suggesting that the protective action involves more than a straightforward free radical-scavenging mechanism. Previous and recent developments in the investigations on the pharmacologic properties of PBN are described in this review.
苯基 N-叔丁基硝酮（PBN）是一类用作自旋捕获剂以捕获自由基的硝酮的母体。PBN 在动物模型中的药理作用广泛，从对内毒素休克后死亡的保护、对缺血再灌注损伤的保护到延长小鼠寿命。最近新增的作用包括对细菌性脑膜炎的保护、沙利度胺诱导的致畸作用、药物诱导的糖尿病发生以及胆碱缺乏性肝癌发生的保护。由于 PBN 与氧自由基反应生成反应性较低的物种，有人认为这是其药理作用的基础。然而，这一观点尚无确凿证据。尽管如此，许多研究人员已将 PBN 药理作用的存在作为自由基参与其模型的证据。对 PBN 抗菌作用的机制研究表明，PBN 抑制多种促炎基因的表达，这表明其保护作用涉及的不仅仅是简单的自由基清除机制。本综述描述了 PBN 药理特性研究的既往和最新进展。
