Vermeire S, Peeters M, Vlietinck R, Joossens S, Den Hond E, Bulteel V, Bossuyt X, Geypens B, Rutgeerts P
Gastroenterology Unit, UZ Gasthuisberg, Leuven, Belgium.
Inflamm Bowel Dis. 2001 Feb;7(1):8-15. doi: 10.1097/00054725-200102000-00002.
Serologic markers anti-Saccharomyces cerevisiae antibodies (ASCA) and antineutrophil cytoplasmic antibodies with perinuclear staining (pANCA) have been proposed to study the immunopathogenesis of IBD. Their measurement may allow better phenotyping of the disease and the detection of subclinical disease.
To test the hypothesis that serological markers identify an immunologic trait related to disease susceptibility. We also wanted to test the hypothesis that ASCA is a marker related to abnormal tissue permeation by common antigens.
We studied the prevalence of pANCA and ASCA in a large cohort of sporadic and familial inflammatory bowel diseases and their unaffected relatives and spouses. Kinetics of ASCA was studied and the relationship between ASCA and 51Cr-EDTA intestinal permeation was investigated.
ASCA was associated with sporadic Crohn's disease (CD) (63%), with Crohn's patients belonging to pure CD families (62%) and also with their unaffected family members (21%). pANCA was associated with UC (58%). The prevalence of ASCA in CD patients belonging to mixed families was strikingly low (33%). ASCA was a stable marker throughout the disease and was not related to an increased small intestinal permeability.
ASCA is strongly associated with familial CD in Belgium, and 21% of healthy family members also display the marker. The association is much weaker in patients belonging to mixed families. ASCA is a stable marker and is not a secondary phenomenon due to increased intestinal permeability.
血清学标志物抗酿酒酵母抗体（ASCA）和核周型抗中性粒细胞胞浆抗体（pANCA）已被用于研究炎症性肠病（IBD）的免疫发病机制。对它们的检测可能有助于更好地对疾病进行表型分析以及发现亚临床疾病。
检验血清学标志物可识别与疾病易感性相关的免疫特征这一假说。我们还想检验ASCA是一种与常见抗原导致的组织异常渗透相关的标志物这一假说。
我们在一大群散发性和家族性炎症性肠病患者及其未患病的亲属和配偶中研究了pANCA和ASCA的患病率。研究了ASCA的动力学，并调查了ASCA与51Cr-EDTA肠道通透性之间的关系。
ASCA与散发性克罗恩病（CD）相关（63%），与属于纯CD家族的克罗恩病患者相关（62%），也与他们未患病的家庭成员相关（21%）。pANCA与溃疡性结肠炎（UC）相关（58%）。属于混合家族的CD患者中ASCA的患病率极低（33%）。ASCA在整个疾病过程中是一个稳定的标志物，且与小肠通透性增加无关。
在比利时，ASCA与家族性CD密切相关，21%的健康家庭成员也显示出该标志物。在属于混合家族的患者中，这种关联要弱得多。ASCA是一个稳定的标志物，并非由肠道通透性增加导致的继发现象。
