Martel J, Darrouzet V, Duclos J Y, Bébéar J P, Stoll D
C.H.U. Pellegrin, Clinique Universitaire O.R.L., Place Amélie Raba Léon, 33076 Bordeaux, France.
Rev Laryngol Otol Rhinol (Bord). 2000;121(4):227-36.
Olfactory neuroblastomas are rare malignant tumours of the nose arising from the olfactory epithelium. In a retrospective series of 18 cases and a review of the literature, the authors establish the main features of this tumour. They emphasise the difficulties of histological examination, often requiring immuno-cyt-chemistery and electron microscopy. They point out the value of a new classification, and confirm treatments being radio-surgical, with use of the combined rhino-neurosurgical approach when there is extension to the cribriform plate. They report a 5-year survival of 91.5%, with 87.5% at 10 years. The high incidence of lymph gland metastases (16.6%) is greater than that of local recurrence (11%) especially in the more advanced cases. The question of prophylactic treatment of the neck nodes is one to be considered.
嗅神经母细胞瘤是起源于嗅上皮的鼻腔罕见恶性肿瘤。在一项对18例病例的回顾性研究及文献综述中，作者确立了该肿瘤的主要特征。他们强调了组织学检查的困难，通常需要免疫细胞化学和电子显微镜检查。他们指出了一种新分类的价值，并确认治疗方式为放射外科治疗，当肿瘤扩展至筛板时采用鼻神经外科联合手术方法。他们报告5年生存率为91.5%，10年生存率为87.5%。淋巴结转移的高发生率（16.6%）高于局部复发率（11%），尤其是在病情较晚期的病例中。颈部淋巴结的预防性治疗问题值得考虑。
