Convery F R, Gunn D R, Hughes J D, Martin W E
J Bone Joint Surg Am. 1975 Jan;57(1):57-64.
Forty patients from a group of seventy elected to participate in a prospective randomized clinical study designed to evaluate the systemic effects of polymethylmethacrylate implanted with a Charnley total hip replacement, utilizing patients treated with a Ring total hip prosthesis ad controls. Intraoperative alterations in cardiovascular function were related to use of methylmethacrylate, but postoperative changes in pulmonary function, erythrocyte sedimentation rate, serum lactic acid dehydrogenase, serum glutamicoxalacetic transaminase, and alkaline phosphatase were not. Charnley total hip replacements were associated with more ectopic-bone formation twelve months postoperatively. The two "latent" infections recognized during the thirty-four months of the study were in hips without acrylic fixation.
在一组70名患者中，40名患者选择参与一项前瞻性随机临床研究，该研究旨在评估采用Charnley全髋关节置换术植入的聚甲基丙烯酸甲酯的全身影响，将采用Ring全髋关节假体治疗的患者作为对照。心血管功能的术中改变与甲基丙烯酸甲酯的使用有关，但术后肺功能、红细胞沉降率、血清乳酸脱氢酶、血清谷草转氨酶和碱性磷酸酶的变化与之无关。Charnley全髋关节置换术后12个月异位骨形成更多。在研究的34个月中发现的两例“潜在”感染发生在未使用丙烯酸固定的髋关节。
