Vignon H, Huguet J, Métafiot H
Ann Anesthesiol Fr. 1978;19(4):279-82.
The aim of this study was to determine whether the prior injection of betamethasone was capable of preventing blood pressure changes and the fall in arterial pO2 when following the fixation of total hip protheses with methyl metacrylate. It involved 54 patients in whom systolic, diastolic and mean blood pressure (BP), arterial pO2, pCO2 and heart rate were noted at different times: T1, 15 minutes after the beginning of the operation; T2 and T3, one minute and five minutes after application of the cement; T4, at the end of the operation. There was no significant difference between the various measurements at times T1, T2, and T3 as far as blood pressure and heart rate were concerned. By contrast, there was a fall in pO2 at times T2 and T2 in relation to times T1 and T4. This fall was significant (p is less than 0.01) but never theless remained moderate. The possible influence of betamethasone is discussed.
本研究的目的是确定在使用甲基丙烯酸甲酯固定全髋关节假体时，预先注射倍他米松是否能够预防血压变化以及动脉血氧分压下降。该研究涉及54名患者，在不同时间记录其收缩压、舒张压和平均血压（BP）、动脉血氧分压、二氧化碳分压和心率：T1，手术开始后15分钟；T2和T3，应用骨水泥后1分钟和5分钟；T4，手术结束时。就血压和心率而言，在T1、T2和T3各测量时间之间没有显著差异。相比之下，与T1和T4相比，T2和T3时血氧分压有所下降。这种下降是显著的（p小于0.01），但仍然是适度的。文中讨论了倍他米松可能产生的影响。
