Czechowicz R T, Warren L J, Moore L, Saxon B
Department of Dermatology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.
Australas J Dermatol. 2001 Feb;42(1):57-9. doi: 10.1046/j.1440-0960.2001.00476.x.
A 3-year-old girl receiving chemotherapy for acute lymphocytic leukaemia developed a rapidly expanding red annular plaque on her thigh, initially without signs of systemic toxicity or local pain. Subsequently she developed Pseudomonas aeruginosa sepsis and purpura at the leading edge of the plaque. Skin biopsy showed an extensive necrotizing vasculitis with numerous Gram-negative bacilli in the blood vessel walls. In immunocompromised individuals, skin biopsy and culture of cutaneous lesions for bacteria and fungi should be considered even in the absence of signs of systemic toxicity or multiple lesions.
一名正在接受急性淋巴细胞白血病化疗的3岁女孩大腿上出现了一个迅速扩大的红色环形斑块，最初没有全身中毒迹象或局部疼痛。随后，她在斑块的前沿出现了铜绿假单胞菌败血症和紫癜。皮肤活检显示广泛的坏死性血管炎，血管壁内有大量革兰氏阴性杆菌。在免疫功能低下的个体中，即使没有全身中毒迹象或多处皮损，也应考虑对皮肤病变进行活检并进行细菌和真菌培养。
