Miller R R
J Clin Pharmacol. 1975 Feb-Mar;15(2-3):198-205. doi: 10.1002/j.1552-4604.1975.tb02357.x.
Of 17,068 hospitalized medical patients monitored in a drug surveillance program, 616 (3.6 per cent) received pentazocine hydrochloride orally and 816 (4.8 per cent) received pentazocine lactate parenterally during one or more admissions. Unsatisfactory analgesic efficacy as judged by each patient's physician was nearly twice as frequent among recipients of pentazocine lactate as among recipients of parenteral morphine or meperidine. Adverse reactions were attributed to pentazocine hydrochloride in 18 recipients (2.9 per cent) and to pentazocine lactate in 37 recipients (4.5 per cent). Neuropsychiatric effects were the most common; they included hallucinations, bizarre feelings, disorientation, and agitation. These effects were dose dependent and frequently serious in nature. Minor gastro-intestinal effects were the second most common adverse reactions.
在一项药物监测项目中，对17068名住院内科患者进行了监测，其中616人（3.6%）在一次或多次住院期间口服了盐酸喷他佐辛，816人（4.8%）接受了乳酸喷他佐辛的肠胃外给药。根据每位患者的医生判断，乳酸喷他佐辛接受者中镇痛效果不佳的频率几乎是肠胃外吗啡或哌替啶接受者的两倍。18名接受者（2.9%）的不良反应归因于盐酸喷他佐辛，37名接受者（4.5%）的不良反应归因于乳酸喷他佐辛。神经精神效应最为常见；包括幻觉、奇异感觉、定向障碍和激动。这些效应具有剂量依赖性，且在性质上往往很严重。轻微的胃肠道效应是第二常见的不良反应。
