Ohnuma I
Department of Ophthalmology, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.
Nippon Ganka Gakkai Zasshi. 2001 Feb;105(2):88-95.
Changes in the macula caused by aging or diabetic retinopathy were studied with scanning laser ophthalmoscope (SLO).
SLO imaging of the macula was done with argon blue, argon green, helium neon, and diode lasers, and the images were recorded on s-VHS video tape. In this study, we examined 29 patients (58 eyes) with no retinal organic change as controls, 8 diabetic patients (16 eyes) without retinopathy, 8 patients (16 eyes) with simple diabetic retinopathy, and 6 patients (12 eyes) with preproliferative diabetic retinopathy.
As age increased, the dark area of the macula was enlarged in the argon blue and argon green images. In diabetic patients, the dark area of the macula in patients in their 30 s and 40 s with retinopathy was larger than in diabetic patients without retinopathy (p < 0.05). The dark area of the macula in preproliferative diabetic retinopathy was larger than in patients in their no diabetic retinopathy or simple diabetic retinopathy (p < 0.05). In the 50 s and 60 s, the dark area of the macula in preproliferative diabetic retinopathy was larger than in the controls or in patients with no diabetic retinopathy (p < 0.05).
The macular dark area became enlarged with aging. In diabetic patients, the dark area of the macula was enlarged in diabetic patients without retinopathy or with progression in diabetic retinopathy stage. Therefore, quantitative assessment of macular appearance with SLO can be used as a new clinical index.
使用扫描激光检眼镜（SLO）研究衰老或糖尿病性视网膜病变引起的黄斑变化。
用氩蓝、氩绿、氦氖和二极管激光器对黄斑进行SLO成像，并将图像记录在s-VHS录像带上。在本研究中，我们检查了29例无视网膜器质性改变的患者（58只眼）作为对照组，8例无视网膜病变的糖尿病患者（16只眼），8例单纯糖尿病性视网膜病变患者（16只眼），以及6例增殖前期糖尿病性视网膜病变患者（12只眼）。
随着年龄增长，氩蓝和氩绿图像中黄斑的暗区扩大。在糖尿病患者中，30多岁和40多岁患有视网膜病变的患者黄斑暗区大于无视网膜病变的糖尿病患者（p < 0.05）。增殖前期糖尿病性视网膜病变患者的黄斑暗区大于无糖尿病性视网膜病变或单纯糖尿病性视网膜病变患者（p < 0.05）。在50多岁和60多岁时，增殖前期糖尿病性视网膜病变患者的黄斑暗区大于对照组或无糖尿病性视网膜病变患者（p < 0.05）。
黄斑暗区随衰老而扩大。在糖尿病患者中，无视网膜病变或糖尿病性视网膜病变进展期患者的黄斑暗区扩大。因此，用SLO对黄斑外观进行定量评估可作为一项新的临床指标。
