Wålinder R, Norbäck D, Wieslander G, Smedje G, Erwall C, Venge P
Department of Medical Sciences, Clinical Physiology, University of Uppsala, Uppsala, Sweden.
Indoor Air. 2001 Mar;11(1):2-9. doi: 10.1034/j.1600-0668.2001.011001002.x.
It has been suggested that certain building factors can be associated with specific exposures, such as dampness, chemical emissions and dust. The aim of the study was to examine the relationships between some selected building factors, on the one hand, and signs of inflammation or obstruction in the upper airways on the other. Acoustic rhinometry and nasal lavage were used in a field study among 234 school personnel in 12 randomly selected schools (participation rate 84%). Eosinophil cationic protein (ECP), lysozyme, albumin and myeloperoxidase (MPO) were analyzed in the lavage fluid. Building related factors selected for the study were: roof inclination, fundament, building construction, signs of water damage, floor material, building age, ceiling height, bookcases and plants in the classroom. Control was made for potential confounders. The results indicate a pattern of nasal responses: less patent noses and an inflammatory biomarker response could be related to flat roof and a concrete slab fundament, factors that are known risk factors for water leakage, building dampness and possibly microbial growth. A reduced nasal patency without an inflammatory biomarker response was related to factors associated with plasticizers and dust. Positive effects were observed for plants in the classroom and in older buildings.
有人提出，某些建筑因素可能与特定暴露有关，如潮湿、化学物质排放和灰尘。本研究的目的是一方面考察一些选定的建筑因素与另一方面上呼吸道炎症或阻塞迹象之间的关系。在一项实地研究中，对12所随机选取学校的234名学校工作人员（参与率84%）使用了鼻声反射测量法和鼻腔灌洗。对灌洗液中的嗜酸性粒细胞阳离子蛋白（ECP）、溶菌酶、白蛋白和髓过氧化物酶（MPO）进行了分析。本研究选取的与建筑相关的因素有：屋顶倾斜度、地基、建筑结构、水损迹象、地面材料、建筑年代、天花板高度、教室中的书柜和植物。对潜在混杂因素进行了控制。结果表明存在一种鼻腔反应模式：鼻腔通畅度降低和炎症生物标志物反应可能与平屋顶和混凝土板地基有关，而这些因素是已知的漏水、建筑潮湿以及可能微生物生长的风险因素。鼻腔通畅度降低但无炎症生物标志物反应与增塑剂和灰尘相关因素有关。在教室和较旧建筑中观察到了植物的积极作用。
