Kunstyr I, Leuenberger H G
J Gerontol. 1975 Mar;30(2):157-62. doi: 10.1093/geronj/30.2.157.
A group of 1,052 C57BL/6J mice (296 males and 756 females) was kept under well-defined, clean laboratory conditions from the age of 6 weeks until natural death. The survival curves of males and females (computer-produced 3, 4, and 5 parameter curves, Gompertz curve histogram) were established and shown to follow a logistic function. The average life-span amounted to 878 plus or minus 10 days for males and 794 plus or minus 6 days for females. These values distinctly exceed comparable values given in the literature. They are attributed to favorable conditions of animal care and to supposed alterations in genetic background. A genetic drift in sex-dependent mean survival time occurred in the genetically unstable C57BL/6J strain between 1966 and 1970. Before this drift, the males died sooner; after it, they lived longer.
一组1052只C57BL/6J小鼠（296只雄性和756只雌性）从6周龄开始饲养在条件明确、清洁的实验室环境中，直至自然死亡。建立了雄性和雌性的生存曲线（计算机生成的三参数、四参数和五参数曲线、冈珀茨曲线直方图），并显示其遵循逻辑函数。雄性的平均寿命为878±10天，雌性为794±6天。这些值明显超过了文献中给出的可比数值。这归因于良好的动物饲养条件以及假定的遗传背景改变。在1966年至1970年间，基因不稳定的C57BL/6J品系出现了性别依赖性平均生存时间的遗传漂变。在这种漂变之前，雄性死亡更早；之后，它们活得更长。
