Nordlund J J, Gershon R K
J Immunol. 1975 May;114(5):1486-90.
The Cloudman (S91) melanoma elicits an immune response in syngeneic DBA/2 mice which prolongs the time before the tumor becomes detectable but does not signigicantly alter the growth rate subsequent to its appearance. The spleen can either enhance the immune response and prolong the lag phase when stimulated with high doses of tumor cells or suppress it and shorten the duration at lower doses. This bidirectional effect of the spleen is similar to previously reported activity of regulatory T cells which reside in the spleen. This observation is discussed in contrast to the role of the spleen in animals bearing tumors which elicit concomitant immunity.
Cloudman（S91）黑色素瘤在同基因DBA/2小鼠中引发免疫反应，这种反应会延长肿瘤可检测到之前的时间，但不会显著改变肿瘤出现后的生长速度。当用高剂量肿瘤细胞刺激时，脾脏可以增强免疫反应并延长延迟期，而在低剂量时则会抑制免疫反应并缩短持续时间。脾脏的这种双向作用类似于先前报道的驻留在脾脏中的调节性T细胞的活性。与脾脏在引发伴随免疫的荷瘤动物中的作用形成对比，对这一观察结果进行了讨论。
