Streilein J W, Niederkorn J Y
J Exp Med. 1981 May 1;153(5):1058-67. doi: 10.1084/jem.153.5.1058.
Anterior chamber-associated immune deviation (ACAID) expresses itself in BALB/c mice inoculated intracamerally with P815 cells in three ways: progressive growth of the tumor within the eye, transient growth of P815 cells injected subcutaneously, and prolonged acceptance of DBA/2 skin allografts. The spleen was found to play a crucial role in the development of ACAID. Splenectomized animals bearing intracameral P815 tumors reject DBA/2 skin grafts in an accelerated manner. A functioning spleen was required during the first 10 d after intracameral inoculation of P815 cells, but not thereafter. Reconstitution experiments revealed that the spleen's ability to support the induction of ACAID depends partly upon its constituent lymphoid cells, but also upon either a stromal component or a unique architectural arrangement that can only be restored with splenic fragments. The data hold promise that therapeutic protocols using appropriately timed splenectomy and specific immunization can be devised to induce hosts bearing intraocular tumors to mount an immune response sufficiently vigorous to destroy the tumor within the eye, and sufficiently precise to preserve the functional and anatomic integrity of the eye.
前房相关免疫偏离（ACAID）在BALB/c小鼠眼内接种P815细胞后以三种方式表现出来：眼内肿瘤的渐进性生长、皮下注射的P815细胞的短暂生长以及对DBA/2皮肤同种异体移植物的长期接受。脾脏在ACAID的发展中起着关键作用。摘除脾脏的动物眼内带有P815肿瘤，会加速排斥DBA/2皮肤移植物。在眼内接种P815细胞后的前10天需要有功能的脾脏，但之后则不需要。重建实验表明，脾脏支持诱导ACAID的能力部分取决于其组成淋巴细胞，也取决于一种基质成分或一种独特的结构排列，而这种排列只能通过脾碎片来恢复。这些数据表明，有望设计出使用适时脾切除术和特异性免疫的治疗方案，以使患有眼内肿瘤的宿主产生足够强烈的免疫反应来破坏眼内肿瘤，并且足够精确以保持眼睛的功能和解剖完整性。
