Nakabayashi T, Uchida S, Maehara T, Hirai N, Nakamura M, Arakaki H, Shimisu H, Okubo Y
Department of Neuropsychiatry, Tokyo Medical and Dental University, Japan.
Psychiatry Clin Neurosci. 2001 Feb;55(1):57-65. doi: 10.1046/j.1440-1819.2001.00785.x.
All-night recordings from subdural electrocorticographic (ECoG) electrodes on the human medial and basal temporal lobes were analysed to examine spindling activities during sleep. Subjects were three males and three females who were candidates for neurosurgical treatments of partial epilepsy. Subdural electrodes were attached to the medial and basal temporal lobe cortices, allowing ECoG and electroencephalogram from the scalp vertex (Cz EEG) to be recorded simultaneously during all night sleep. In one case, subdural electrodes were attached also on the parietal lobe. Fast Fourier transformation (FFT) analyses were performed on the ECoG and Cz EEG signals. No organized sleep spindles or sigma band (12-16 Hz) peaks in FFT power spectra were observed from the medial or basal temporal lobes of the non-epileptogenic hemispheres during non-rapid eye movement (NREM) sleep. In a case with parietal electrodes, organized spindle bursts were observed in parietal signals synchronized with Cz spindles. Although delta band (0.3-3 Hz) power from both the medial and basal temporal lobes fluctuated across each night as expected, sigma activity changed little. However, 14 Hz oscillatory bursts were observed in the medial basal temporal lobe of epileptogenic hemisphere in two cases and bilaterally in one case during not only NREM sleep but rapid eye movement (REM) sleep and wakefulness. From the present study we conclude that sleep spindle activities are absent in the medial and basal temporal lobes. Fourteen Hz oscillatory bursts observed from the medial or basal temporal lobe in some cases were not considered to be sleep spindles since they also appeared during REM sleep and wakefulness. These waveforms could have originated due to epileptic pathology, since they frequently appeared in epileptic regions.
对人类内侧和基底颞叶硬膜下皮质脑电图（ECoG）电极进行的全夜记录进行了分析，以检查睡眠期间的纺锤波活动。受试者为三名男性和三名女性，他们均为部分性癫痫神经外科治疗的候选者。硬膜下电极附着于内侧和基底颞叶皮质，从而在全夜睡眠期间能够同时记录ECoG和头皮顶点脑电图（Cz脑电图）。在一个病例中，硬膜下电极也附着于顶叶。对ECoG和Cz脑电图信号进行了快速傅里叶变换（FFT）分析。在非快速眼动（NREM）睡眠期间，从非致痫半球的内侧或基底颞叶未观察到FFT功率谱中有组织化的睡眠纺锤波或西格玛频段（12 - 16赫兹）峰值。在一个有顶叶电极的病例中，观察到顶叶信号中与Cz纺锤波同步的有组织的纺锤波爆发。尽管内侧和基底颞叶的δ频段（0.3 - 3赫兹）功率每晚如预期那样波动，但西格玛活动变化不大。然而，在两个病例中，在致痫半球的内侧基底颞叶观察到14赫兹振荡爆发，在一个病例中双侧观察到，不仅在NREM睡眠期间，而且在快速眼动（REM）睡眠和清醒状态下也有。从本研究中我们得出结论，内侧和基底颞叶不存在睡眠纺锤波活动。在某些病例中从内侧或基底颞叶观察到的14赫兹振荡爆发不被认为是睡眠纺锤波，因为它们在REM睡眠和清醒状态下也会出现。这些波形可能源于癫痫病理，因为它们经常出现在癫痫区域。
