Nishida Masaki, Hirai Nobuhide, Miwakeichi Fumikazu, Maehara Taketoshi, Kawai Kensuke, Shimizu Hiroyuki, Uchida Sunao
Department of Sleep Disorders Research, Tokyo Institute of Psychiatry, Tokyo, Japan.
Neurosci Res. 2004 Nov;50(3):331-41. doi: 10.1016/j.neures.2004.08.004.
Ten epileptic patients each with subdural electrodes surgically attached to the anterior cingulate cortex (ACC; two cases), the orbitofrontal cortex (OFC; seven cases), or both (one case) were included in this study. We recorded each patient's ACC or OFC electrocorticogram (ECoG) during the time period that the patient was awake and naturally asleep. We performed a Fast Fourier Transformation (FFT) power spectral analysis on each ECoG to examine its frequency component. We found that the ACC showed regular and continuous theta oscillation (5-7Hz) during wakefulness and rapid eye movement (REM) sleep, but not during slow wave sleep. Theta waves observed in REM sleep were not as distinct as those found in wakefulness. We also discovered that the orbitofrontal signals represented spectral peaks in the theta band only during wakefulness. This suggests the coexistence of theta oscillation in the ACC. Considering our previous observations of gamma and beta oscillations in the human hippocampus, we hypothesize that the human limbic system manifests two oscillatory activities. The results obtained in this study suggest that electrophysiological activity in the ACC could be related to particular psychological functions in wakefulness and in REM sleep. These results are useful in elucidating the human brain mechanism.
本研究纳入了10例癫痫患者，他们均通过手术将硬膜下电极连接至前扣带回皮质（ACC；2例）、眶额叶皮质（OFC；7例）或两者（1例）。我们在患者清醒和自然睡眠期间记录其ACC或OFC的皮质脑电图（ECoG）。我们对每个ECoG进行快速傅里叶变换（FFT）功率谱分析，以检查其频率成分。我们发现，ACC在清醒和快速眼动（REM）睡眠期间表现出规则且持续的θ振荡（5-7Hz），但在慢波睡眠期间则没有。在REM睡眠中观察到的θ波不如在清醒时那么明显。我们还发现，眶额叶信号仅在清醒期间在θ波段表现出频谱峰值。这表明ACC中存在θ振荡。考虑到我们之前对人类海马体中γ和β振荡的观察，我们假设人类边缘系统表现出两种振荡活动。本研究获得的结果表明，ACC中的电生理活动可能与清醒和REM睡眠中的特定心理功能有关。这些结果有助于阐明人类大脑机制。
