Nakamura Motoaki, Uchida Sunao, Maehara Taketoshi, Kawai Kensuke, Hirai Nobuhide, Nakabayashi Tetsuo, Arakaki Hiroshi, Okubo Yoshiro, Nishikawa Toru, Shimizu Hiroyuki
Department of Psychiatry and Behavioral Science, Tokyo Medical and Dental University, Tokyo, Japan.
Neurosci Res. 2003 Apr;45(4):419-27. doi: 10.1016/s0168-0102(03)00007-5.
To investigate the sleep spindle activity of the human prefrontal cortex (PFC), we simultaneously recorded whole nights of polysomnographic and electrocorticographic (ECoG) activities during the natural sleep of epileptic patients. Subjects were nine patients with intractable epilepsy who had subdural electrodes surgically attached to the orbital (seven cases), medial (three cases), or dorsolateral (two cases) PFC, and in one case to the frontal pole. To examine spindle frequencies, fast Fourier transformation (FFT) and auto-correlation analyses were performed on the PFC ECoG and Cz EEG data, primarily on epochs of stage 2 sleep. Lower sigma band ECoG oscillations of about 12 Hz were widely distributed across all prefrontal cortical areas including the frontal limbic regions, but none of the PFC sigma frequency peaks coincided with the faster (about 14 Hz) Cz EEG sleep spindles. Combining our results with anatomical and electrophysiological facts, it is suggested that the thalamofrontal circuit involving the rostral reticular and the mediodorsal nucleus of the thalamus is responsible for the generation of 12 Hz frontal spindles in humans.
为了研究人类前额叶皮质（PFC）的睡眠纺锤波活动，我们在癫痫患者自然睡眠期间同步记录了整晚的多导睡眠图和皮质电图（ECoG）活动。研究对象为9例难治性癫痫患者，他们通过手术将硬膜下电极连接至眶部（7例）、内侧（3例）或背外侧（2例）前额叶皮质，1例连接至额极。为了检测纺锤波频率，主要对第二阶段睡眠时期的前额叶皮质ECoG和Cz脑电图数据进行了快速傅里叶变换（FFT）和自相关分析。约12Hz的较低西格玛频段ECoG振荡广泛分布于包括额叶边缘区域在内的所有前额叶皮质区域，但前额叶皮质的西格玛频率峰值均未与更快的（约14Hz）Cz脑电图睡眠纺锤波重合。结合我们的研究结果以及解剖学和电生理学事实，提示涉及丘脑嘴侧网状核和丘脑背内侧核的丘脑前额叶回路负责人类12Hz额叶纺锤波的产生。
