Barr H M, Streissguth A P
Department of Psychiatry and Behavioral Sciences, Fetal Alcohol and Drug Unit, University of Washington School of Medicine, Seattle 98195, USA.
Alcohol Clin Exp Res. 2001 Feb;25(2):283-7.
The incidence of Fetal Alcohol Syndrome (FAS) has been estimated at 1 to 3 per 1,000 live births. Fetal Alcohol Spectrum Disorders (FASD) (which include FAS) are estimated to occur in about 1 in 100 births. Cessation of drinking during pregnancy can improve the outcome even if the unborn child is already affected. For individuals born with FASD, an early diagnosis appears to be a protective factor against secondary disabilities. A quick screening tool to identify newborn children at risk has been elusive.
A simple descriptive presentation is offered that shows where 36 individuals with FASD were found from among the many patterns and amounts of prenatal alcohol use that were reported by a sample of 1,439 pregnant women whose offspring were later examined within the first 7 years of life.
Individuals with FASD (i.e., those with FAS, fetal alcohol effects, alcohol-related neurodevelopmental disorder ) were found within two aggregates of alcohol scores that together recommend a set of three to four alcohol questions. Within this derivation sample, one scoring of the questions yields almost 78% sensitivity and 97% specificity for FASD. Another scoring of the same instrument yields 100% sensitivity with 90% specificity.
These new data may facilitate early identification of offspring who may be most in need of early intervention, namely those born with FASD.
据估计，胎儿酒精综合征（FAS）的发病率为每1000例活产中有1至3例。胎儿酒精谱系障碍（FASD，包括FAS）估计约每100例出生中就有1例发生。孕期戒酒即使对已受影响的未出生胎儿也能改善结局。对于患有FASD的个体，早期诊断似乎是预防继发性残疾的保护因素。一种用于识别有风险新生儿的快速筛查工具一直难以找到。
提供了一种简单的描述性呈现方式，展示了在1439名孕妇样本报告的众多产前饮酒模式和饮酒量中，如何从其后代在生命的前7年内接受检查的情况中找出36名患有FASD的个体。
在两个酒精评分汇总中发现了患有FASD的个体（即患有FAS、胎儿酒精影响、酒精相关神经发育障碍的个体），这两个汇总共同推荐了一组三到四个关于酒精的问题。在这个推导样本中，对这些问题的一种计分方式对FASD的敏感性几乎达到78%，特异性达到97%。对同一工具的另一种计分方式敏感性为100%，特异性为90%。
这些新数据可能有助于早期识别那些最需要早期干预的后代，即患有FASD的个体。
