南美洲印第安人中细胞色素P4501A1的多态性

Cytochrome P4501A1 polymorphisms in South American Indians.

作者信息

Kvitko K, Nunes J C, Weimer T A, Salzano F M, Hutz M H

机构信息

Departamento de Genética, Instituto De Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Hum Biol. 2000 Dec;72(6):1039-43.

PMID:11236859

Abstract

A total of 131 individuals from five Brazilian Indian tribes were studied for two CYP1A1 gene polymorphisms. The presence of the *val allele at codon 462 varied from 54% in the Surui to 97% in the Xavante, while the presence of the MspI restriction site (*m2 allele) at position T6235C ranged from 72% in the Gavião to 95% in the Xavante. The haplotypes derived from these two sites showed a highly heterogeneous distribution among the five populations. The most common haplotype in South Amerindians was *val/*m2 (54% to 94%). This prevalence is the highest that has been observed in any world population.

摘要

对来自巴西五个印第安部落的131人进行了两种CYP1A1基因多态性研究。密码子462处*val等位基因的存在比例在苏鲁伊部落中为54%，在沙万提部落中为97%；而在T6235C位置的MspI限制性位点（m2等位基因）的存在比例在加维昂部落中为72%，在沙万提部落中为95%。这两个位点衍生的单倍型在这五个群体中呈现出高度异质性分布。南美印第安人中最常见的单倍型是val/*m2（54%至94%）。这种流行率是在世界任何人群中观察到的最高值。