嚼食槟榔作为肝细胞癌的一个风险因素：一项病例对照研究。
Betel quid chewing as a risk factor for hepatocellular carcinoma: a case-control study.
作者信息
Tsai J F, Chuang L Y, Jeng J E, Ho M S, Hsieh M Y, Lin Z Y, Wang L Y
机构信息
Department of Internal Medicine, Kaohsiung Medical University College of Medicine, Taiwan, Republic of China.
出版信息
Br J Cancer. 2001 Mar 2;84(5):709-13. doi: 10.1054/bjoc.1999.1597.
Abstract
The role of betel quid chewing in the aetiology of hepatocellular carcinoma (HCC) was evaluated in a case-control study including 263 pairs of age- and sex-matched HCC patients and healthy controls. Serum hepatitis B surface antigen (HBsAg), and antibodies to hepatitis C virus (anti-HCV) were determined, and standardized personal interview conducted using a structured questionnaire. Multivariate analysis indicated that betel quid chewing (odds ratio (OR), 3.49; 95% confidence interval (CI), 1.74-6.96), HBsAg (OR, 16.69; 95% CI, 9.92-28.07), anti-HCV (OR, 38.57; 95% CI, 18.15-81.96), and educational duration of less than 10 years (OR, 1.71; 95% CI, 1.05-2.78) are independent risk factors of HCC. In addition, there was an additive interaction between betel quid chewing and chronic infection with either hepatitis B virus (synergy index, 5.37) or hepatitis C virus (synergy index, 1.66). Moreover, risk on HCC increased as duration of betel quid chewing increased, or amount of betel quid consumed (each P for trend < 0.0001).
摘要
在一项病例对照研究中，对嚼槟榔在肝细胞癌（HCC）病因学中的作用进行了评估，该研究纳入了263对年龄和性别匹配的HCC患者及健康对照。检测了血清乙肝表面抗原（HBsAg）和丙肝病毒抗体（抗-HCV），并使用结构化问卷进行标准化个人访谈。多因素分析表明，嚼槟榔（比值比（OR）为3.49；95%置信区间（CI）为1.74 - 6.96）、HBsAg（OR为16.69；95% CI为9.92 - 28.07）、抗-HCV（OR为38.57；95% CI为18.15 - 81.96）以及教育年限少于10年（OR为1.71；95% CI为1.05 - 2.78）是HCC的独立危险因素。此外，嚼槟榔与乙肝病毒慢性感染（协同指数为5.37）或丙肝病毒慢性感染（协同指数为1.66）之间存在相加交互作用。而且，HCC风险随着嚼槟榔时间的延长或槟榔消耗量的增加而升高（各趋势P值均<0.0001）。
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