Effler P, Ieong M C, Kimura A, Nakata M, Burr R, Cremer E, Slutsker L
Epidemiology Branch, State Health Department, Honolulu, HI 96813, USA.
J Infect Dis. 2001 Apr 1;183(7):1152-5. doi: 10.1086/319292. Epub 2001 Feb 28.
Campylobacter is the most common cause of bacterial foodborne illness in the United States, and Hawaii has the highest rate of Campylobacter jejuni infections in the nation. A case-control study was conducted to determine indigenous exposures that contribute to the high incidence of sporadic C. jejuni infection in Hawaii. A total of 211 case patients with diarrhea and confirmed Campylobacter infection was enrolled, along with 1 age- and telephone exchange-matched control subject for each patient. Participants were interviewed about illness, medicines, food consumption, food-handling practices, and exposure to animals. In matched logistic regression analyses, eating chicken prepared by a commercial food establishment in the 7 days before case illness onset (adjusted odds ratio [AOR], 1.8; P=.03) and consuming antibiotics during the 28 days before illness onset (AOR, 3.3; P=.03) were significant independent predictors of illness. Further study of the association of Campylobacter illness with commercially prepared chicken and prior antibiotic use is needed.
弯曲杆菌是美国细菌性食源性疾病最常见的病因，而夏威夷的空肠弯曲菌感染率在全美最高。开展了一项病例对照研究，以确定导致夏威夷散发性空肠弯曲菌感染高发的本地暴露因素。共纳入了211例腹泻且确诊为弯曲杆菌感染的病例患者，为每位患者匹配1名年龄和电话局号相匹配的对照对象。就疾病、用药、食物摄入、食品处理习惯以及动物接触情况对参与者进行了访谈。在配对逻辑回归分析中，发病前7天食用商业食品机构制作的鸡肉（校正比值比[AOR]，1.8；P = 0.03）以及发病前28天使用抗生素（AOR，3.3；P = 0.03）是疾病的显著独立预测因素。需要进一步研究弯曲杆菌病与商业制作的鸡肉以及既往使用抗生素之间的关联。
