Grundsell H, Håkansson L
Acta Obstet Gynecol Scand. 1975;54(2):173-81. doi: 10.3109/00016347509156751.
The present investigation studied the influence of different types of intra-uterine devices (IUDs) especially that of a copper IUD, on the incorporation of 3-H-thymidine and 5-3-H-uridine into the endometrium of the rabbit. "Inert" IUD. In non-stimulated rabbits, the incorporation of 3-H-thymidine was increased in the copper influenced horn. The incorporation of 3H-thymidine in control and Cu-IUD-containing horns reached a maximum at 48 hours after HCG stimulation, but was significantly lower in the copper-containing horn than in the control horn. On the fifth day of pseudopregnancy, the incorporation of 3-H-thymidine was significantly higher in the copper IUD-containing horn. The total amount of DNA in the endometrium increased during early pseudopregnancy, but this increase was markedly reduced in the presence of copper. The copper IUD had no influence on the rate of incorporation of 5-3-H-uridine in non-stimulated rabbits, whereas it caused a higher incorporation on the fifth day of pseudopregnancy.
本研究探讨了不同类型的宫内节育器（IUD），尤其是铜质宫内节育器，对3 - H - 胸腺嘧啶核苷和5 - 3 - H - 尿苷掺入兔子宫内膜的影响。“惰性”宫内节育器。在未受刺激的兔子中，铜质影响侧子宫角中3 - H - 胸腺嘧啶核苷的掺入量增加。在人绒毛膜促性腺激素（HCG）刺激后48小时，对照侧和含铜宫内节育器侧子宫角中3H - 胸腺嘧啶核苷的掺入量达到最大值，但含铜侧子宫角中的掺入量显著低于对照侧子宫角。在假孕第5天，含铜宫内节育器侧子宫角中3 - H - 胸腺嘧啶核苷的掺入量显著更高。在假孕早期，子宫内膜中的DNA总量增加，但在有铜存在的情况下，这种增加明显减少。铜质宫内节育器对未受刺激的兔子中5 - 3 - H - 尿苷的掺入速率没有影响，而在假孕第5天，它会导致更高的掺入量。
