Tobert J A, Davies D R
J Reprod Fertil. 1977 May;50(1):53-9. doi: 10.1530/jrf.0.0500053.
The response of the rabbit endometrium to the copper IUD was investigated. A plastic IUD bearing copper foil (42 mm2) was inserted into one horn of the rabbit uterus and a physically similar platinum-bearing IUD in the contralateral horn served as a control. The Pt-IUD caused no tissue damage and little if any inflammatory reaction in ovariectomized, oestrous or pregnant animals, whereas the Cu-IUD produced endometrial ulcers in 14 out of 15 does in all hormonal states. The associated inflammation was particularly intense in the pregnant animals in which a unilateral pyometra was usually present. Despite the endometrial trauma produced, the Cu-IUD was only partly effective as a contraceptive agent, 36% of the ova shed from the ovary ipsilateral to the Cu-IUD implanting, compared with 63% of the ova ipsilateral to the Pt-IUD. However, almost half of the implantation swellings in the copper-bearing horns were abnormally small or distorted in shape at 9 days post coitum. The tissue destruction observed in the rabbit endometrium emphasizes the need for careful histological studies of the effect of the copper IUD on the human uterus.
研究了兔子宫内膜对铜宫内节育器（IUD）的反应。将带有铜箔（42平方毫米）的塑料IUD插入兔子宫的一个角，在对侧角插入一个物理性质相似的含铂IUD作为对照。在去卵巢、发情或怀孕的动物中，铂IUD不会引起组织损伤，也几乎不会引起炎症反应，而铜IUD在所有激素状态下，15只母兔中有14只出现了子宫内膜溃疡。在怀孕动物中，相关炎症尤为强烈，通常会出现单侧子宫积脓。尽管产生了子宫内膜创伤，但铜IUD作为一种避孕剂仅部分有效，与铂IUD同侧卵巢排出的卵子中有63%相比，铜IUD植入侧卵巢排出的卵子中有36%。然而，在交配后9天，含铜角中的植入肿胀几乎有一半异常小或形状扭曲。在兔子宫内膜中观察到的组织破坏强调了对铜IUD对人类子宫影响进行仔细组织学研究的必要性。
