Pogosianz H E
J Natl Cancer Inst. 1975 Mar;54(3):659-64. doi: 10.1093/jnci/54.3.659.
The Djungarian hamster, bred under usual laboratory conditions, developed different spontaneous neoplasms, most often mammary and skin cancers. Some mammary tumors were serially transplanted to noninbred animals. This hamster was susceptible to some chemical carcinogens and oncogenic viruses but resistant to others. It had comparatively few chromosomes (2n equal to 28), most of which could be recognized even in conventionally stained preparations. The chromosome-breaking effect of gamma-rays, chemical carcinogens, and viruses was studied with primary cultures of cells. Several transformed cell lines were developed. Karyotype abnormalities were generally not seen in primary and induced neoplasms. This hamster is a new suitable tool for cancer research and cytogenetic studies.
在常规实验室条件下饲养的黑线仓鼠会发生不同的自发性肿瘤，最常见的是乳腺癌和皮肤癌。一些乳腺肿瘤被连续移植到非近交系动物身上。这种仓鼠对某些化学致癌物和致癌病毒敏感，但对其他一些则有抗性。它的染色体相对较少（2n等于28），即使在常规染色的标本中，大多数染色体也能被识别。利用细胞原代培养研究了γ射线、化学致癌物和病毒的染色体断裂效应。建立了几个转化细胞系。在原发性和诱导性肿瘤中一般未见核型异常。这种仓鼠是癌症研究和细胞遗传学研究的一种新的合适工具。
