Kondo Hirotaka, Onuma Mamoru, Ito Hidetoshi, Shibuya Hisashi, Sato Tsuneo
Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
Comp Med. 2008 Jun;58(3):294-6.
A 1.5-y-old female Djungarian hamster (Phodopus sungorus) presented with a large subcutaneous mass surrounding the right shoulder. Radiography revealed dislocation of the right humeral articulation and osteolytic lesions of the right scapula. Histologically, the mass was composed of spindle to stellate cells arranged in fascicles interwoven with delicate collagen fibers, and neoplastic cells infiltrated the bone, skeletal muscle, and subcutaneous tissues. Neoplastic cells stained intensely positive for vimentin and negative for S100 protein, neurofilament, and desmin. A minority of neoplastic cells (10% to 20%) stained moderately for smooth muscle actin. The mass was diagnosed as a fibrosarcoma. Although fibrosarcomas are relatively common in dogs and cats, this is the first report of fibrosarcoma in a domestic Djungarian hamster.
一只1.5岁的雌性侏儒仓鼠（Phodopus sungorus）右肩部周围出现一个巨大的皮下肿块。X线摄影显示右肱骨关节脱位及右肩胛骨溶骨性病变。组织学上，肿块由梭形至星状细胞组成，细胞呈束状排列，与纤细的胶原纤维交织，肿瘤细胞浸润骨、骨骼肌和皮下组织。肿瘤细胞波形蛋白染色呈强阳性，S100蛋白、神经丝蛋白和结蛋白染色呈阴性。少数肿瘤细胞（10%至20%）平滑肌肌动蛋白染色呈中度阳性。该肿块被诊断为纤维肉瘤。虽然纤维肉瘤在犬猫中相对常见，但这是家养侏儒仓鼠发生纤维肉瘤的首例报道。
